Optimized for medium-polarity compounds
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Sample solution is nebulized into fine droplets, rapidly vaporized into gaseous neutral molecules in a heated evaporation tube. Under corona discharge (2-5 kV):Ambient gases (N₂/H₂O) ionize → Primary ions form (H₃O⁺/O₂⁻), Reagent ions collide with analyte molecules, Ionization occurs via: Proton transfer (positive mode): [M+H]⁺; Electron capture (negative mode): [M-H]⁻.
Complements ESI's inherent limitations by delivering robust ionization for nonpolar/low-polarity small molecules, particularly effective for thermally stable and volatile compounds.
